Job Description
Job Description
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking a Scientist to join the GLP Bioanalytical group within the Clinical Pharmacology and DMPK Department. The successful candidate will focus on internal bioanalytical method transfer, qualification/validation, and sample analysis for pharmacokinetic studies for early and late development phase programs. S/He will have expertise with various analytical platforms including LC/MS/MS, LC-FL, or immunoassays and is well versed in GxP bioanalysis. S/He will interface with different teams to coordinate sample analysis according to the study needs and timelines. S/He will be joining a team of highly motivated and experienced scientists and will contribute to the success of Arrowhead development programs.
Responsibilities
- Conduct method development/transfer, qualification/validation, and sample analysis of bioanalytical assays via LC-FL, LC/MS/MS or other platforms for non-clinical and clinical studies.
- Perform scientific data review and interpretation. Troubleshoot abnormal data and complex method issues as needed
- Setup and maintain lab instrumentation and organization
- Track progress against project timelines, generate regular status updates, and communicate progress and issues to management and cross-functional teams
- Engage in implementation of new analytical platforms
- Engage in development of workflows and procedures
- Effectively manage workload with minimal supervision. Multi-task across several projects and manage time effectively to achieve results.
- Follow SOPs and stay up to date on regulations. Adhere to Arrowhead values and Good Documentation Practices
- Adhere to safe laboratory practices
Requirements:
- B.S. in Chemistry (or related field)
- 5+ years of relevant GxP experience, M.S. in Chemistry (or related field) with 3+ years of relevant GxP experience.
- Familiarity with GxP regulations and approaches to method validations, sample analysis, and data processing
- Good documentation practices with excellent organization and attention to detail
- Demonstrated innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with a can-do mindset and the ability to thrive in a fast paced, dynamic, multi-disciplinary, matrixed environment
Preferred:
- Method development or troubleshooting experience with various analytical platforms
- Project management experience, e.g. principal investigator for bioanalytical studies
- Experience with training other scientists and leading lab organization and processes
- Experience with sample management under GxP environment
Wisconsin pay range $95,000—$115,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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