Sr/Prin Scientist, Protein Production & Characterization

EVOLVEIMMUNE THERAPEUTICS INC

Branford, CT, USA

Published: 6/14/2022

Science

Full Time

Job Description

Location: Onsite | Branford, CT | Full-Time

Join a company where your science will directly shape the future of cancer immunotherapy.

Who We Are

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, is anticipated to enter clinical trials in Fall 2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of over 47 FTEs in R&D, business development and operations with immediate plans for additional growth. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor.

We're hiring a Senior or Principal Scientist to join our Biotherapeutics team collaborative group focused on designing and advancing first-in-class immune-engaging biologics. If you’re a protein scientist with expertise in protein production who thrives in the lab and wants your work to move swiftly toward patients, this role offers real opportunity, purpose, and scientific challenge.

What You’ll Work On

Lead antibody production from idea to construct to bench — including expression, purification, and characterization
Optimize expression and purification methodologies (affinity, IEX, SEC, etc.) for novel antibodies and multispecific formats that power our next-generation immunotherapies
Contribute to developability assessments with platforms like SPR, BLI, DSC, DLS, ciEF, and LC-MS
Improve key attributes like affinity, stability, specificity, and PK using modern tools and data
Collaborate across functional teams to support candidate selection and preclinical development
Develop and refine functional assays for biologic characterization
Present findings in a clear, compelling way to multidisciplinary teams
Mentor junior scientists and help shape our growing discovery organization

What You Bring

PhD in Biochemistry or a related field and 5+ years of industry experience (or)
MS with 10+ years in antibody production roles
Strong expertise with mammalian expression systems (e.g., CHO/HEK)
Strong expertise in protein purification methodologies (affinity, IEX, SEC) and instruments (AKTA-Pure, AKTA-Avants). Experience with AKTA automation is a plus (method writing, semi-automated multi-step purification)
Experience with bispecific or multispecific formats and familiarity with T cell engagers
Strong communication, data interpretation, and cross-functional collaboration skills
Experience with cell-based assays and/or phage/yeast display is valuable
Experience with LCMS analysis of antibodies/multispecifics is a plus
Working knowledge of structure–activity relationships and/or molecular modeling is a plus

What You’ll Gain

A hands-on, high-impact role shaping the design of next-generation immunotherapies
Opportunity to see your work move rapidly from concept to clinic
A visible position within the Biotherapeutics team, contributing directly to platform and pipeline innovation
A chance to collaborate across disciplines and influence key program decisions
Professional growth through exposure to diverse scientific challenges and cross-functional projects
Mentorship opportunities and the ability to help shape a growing discovery organization
A mission-driven, fast-paced biotech environment that values bold thinking and scientific excellence
A supportive, open culture built on collaboration, trust, and shared purpose

Why You’ll Love Working Here

Direct impact: Your ideas and experiments will influence platform design and help shape clinical programs
Cutting-edge science: Work on a truly novel immunotherapy approach in a scientifically rigorous, fast-moving environment
Personal growth: Take on visible, high-impact projects in a startup culture where contributions are recognized and development is supported
Collaborative culture: Join a tight-knit, mission-driven team that values open communication, learning, and teamwork
Top-tier facilities: Enjoy working in our brand-new, purpose-built lab space just outside New Haven, CT
Mission with meaning: Be part of a company working to give more patients real hope in the fight against cancer

Additional Info

This is a full-time, onsite position based in Branford, CT
EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered
We offer competitive salary, benefits, equity, and paid time off
We are an equal opportunity employer and value diverse perspectives in all aspects of our work

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